Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_832 Exclusive	ad_gs_25	1.21e-01	8.55e-02	4.84e-03	1.33e-04
ad_gs_25 Exclusive	10000run_2_832	1.74e-02	3.24e-02	1.02e-09	9.02e-07
10000run_2_832 Exclusive	ad_gs_25 Exclusive	1.08e-01	1.27e-01	6.91e-03	7.49e-04
ad_gs_25 Exclusive	10000run_2_832 Exclusive	1.30e-02	4.16e-02	6.85e-09	1.97e-06
10000run_2_832 Exclusive	Overlap	9.08e-01	7.89e-01	8.36e-01	1.32e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	3.91e-01	3.44e-02	3.22e-66	2.17e-07



Evaluating how well 10000run_2_832 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_832 Exclusive	ad_gs_25	0.78	2.35	3.86	2.53	4.59
ad_gs_25 Exclusive	10000run_2_832	0.55	1.41	1.83	1.70	4.66
10000run_2_832 Exclusive	ad_gs_25 Exclusive	0.78	2.87	3.62	2.47	4.71
ad_gs_25 Exclusive	10000run_2_832 Exclusive	0.54	1.49	1.78	1.49	4.96
10000run_2_832 Exclusive	Overlap	0.82	0.64	0.47	0.78	1.82
ad_gs_25 Exclusive	Overlap	1.00	3.14	2.06	2.97	2.77
Overlap	Exclusives	0.56	1.87	2.92	1.65	5.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_832 Exclusive	ad_gs_25	0.00	1.83	4.92	2.92	6.91
ad_gs_25 Exclusive	10000run_2_832	0.05	1.69	2.41	2.65	4.66
10000run_2_832 Exclusive	ad_gs_25 Exclusive	0.00	3.46	5.01	2.41	5.57
ad_gs_25 Exclusive	10000run_2_832 Exclusive	0.05	1.48	1.96	1.86	4.23
10000run_2_832 Exclusive	Overlap	0.00	0.73	0.75	1.50	4.76
ad_gs_25 Exclusive	Overlap	0.03	77.11	57.21	156.25	22.92
Overlap	Exclusives	0.06	6.47	6.52	4.34	8.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_832 Exclusive	828	825	C19orf84;PTGES3L-AARSD1;STON1-GTF2A1L
ad_gs_25 Exclusive	22	22	
Overlap	3	3