Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_1_678 Exclusive	ad_gs_25	3.23e-02	3.76e-02	5.89e-04	4.40e-06
ad_gs_25 Exclusive	10000run_2_1_678	6.41e-02	2.60e-02	7.42e-08	2.61e-07
10000run_2_1_678 Exclusive	ad_gs_25 Exclusive	3.12e-02	3.58e-02	5.03e-04	1.13e-05
ad_gs_25 Exclusive	10000run_2_1_678 Exclusive	4.83e-02	3.34e-02	5.24e-08	4.22e-07
10000run_2_1_678 Exclusive	Overlap	8.75e-01	7.89e-01	6.12e-01	9.38e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.30e-01	8.59e-02	2.41e-57	1.40e-07



Evaluating how well 10000run_2_1_678 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_1_678 Exclusive	ad_gs_25	0.81	3.12	4.26	2.85	5.18
ad_gs_25 Exclusive	10000run_2_1_678	0.56	2.13	2.96	2.18	4.76
10000run_2_1_678 Exclusive	ad_gs_25 Exclusive	0.80	3.67	4.57	2.69	5.25
ad_gs_25 Exclusive	10000run_2_1_678 Exclusive	0.55	1.94	2.35	1.85	5.97
10000run_2_1_678 Exclusive	Overlap	0.84	1.09	0.37	1.20	2.14
ad_gs_25 Exclusive	Overlap	1.00	2.85	2.46	2.90	3.08
Overlap	Exclusives	0.56	1.81	2.64	1.38	5.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_1_678 Exclusive	ad_gs_25	0.01	3.21	7.55	4.04	4.27
ad_gs_25 Exclusive	10000run_2_1_678	0.04	3.06	4.10	3.74	6.11
10000run_2_1_678 Exclusive	ad_gs_25 Exclusive	0.00	5.00	8.18	3.82	8.31
ad_gs_25 Exclusive	10000run_2_1_678 Exclusive	0.04	2.36	2.97	2.68	6.63
10000run_2_1_678 Exclusive	Overlap	0.00	1.00	3.80	1.32	7.07
ad_gs_25 Exclusive	Overlap	0.03	134.65	73.73	103.83	69.45
Overlap	Exclusives	0.05	9.09	7.27	5.36	9.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_1_678 Exclusive	675	673	STON1-GTF2A1L;PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3