Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_3_435 Exclusive	ad_gs_25	2.42e-04	4.80e-05	2.68e-06	1.13e-07
ad_gs_25 Exclusive	10000run_2_3_435	3.29e-01	3.93e-02	1.07e-06	5.59e-06
10000run_2_3_435 Exclusive	ad_gs_25 Exclusive	6.60e-04	5.65e-05	8.59e-06	3.65e-06
ad_gs_25 Exclusive	10000run_2_3_435 Exclusive	3.26e-01	7.61e-02	1.21e-06	2.06e-06
10000run_2_3_435 Exclusive	Overlap	3.50e-01	3.98e-01	1.65e-01	1.42e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.63e-01	2.60e-02	1.18e-45	2.06e-07



Evaluating how well 10000run_2_3_435 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_3_435 Exclusive	ad_gs_25	0.84	4.32	5.40	3.61	6.34
ad_gs_25 Exclusive	10000run_2_3_435	0.57	2.11	2.83	2.09	4.41
10000run_2_3_435 Exclusive	ad_gs_25 Exclusive	0.83	3.41	4.91	3.12	5.04
ad_gs_25 Exclusive	10000run_2_3_435 Exclusive	0.56	1.80	2.09	2.15	4.26
10000run_2_3_435 Exclusive	Overlap	0.90	1.93	1.50	1.95	2.14
ad_gs_25 Exclusive	Overlap	1.00	3.46	2.40	2.73	3.28
Overlap	Exclusives	0.58	2.38	3.67	2.24	5.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_3_435 Exclusive	ad_gs_25	0.01	7.48	13.02	9.76	8.04
ad_gs_25 Exclusive	10000run_2_3_435	0.03	4.71	5.53	5.20	5.90
10000run_2_3_435 Exclusive	ad_gs_25 Exclusive	0.01	7.90	10.51	9.30	5.69
ad_gs_25 Exclusive	10000run_2_3_435 Exclusive	0.03	3.10	3.70	3.92	4.95
10000run_2_3_435 Exclusive	Overlap	0.00	0.68	8.63	2.04	4.11
ad_gs_25 Exclusive	Overlap	0.03	68.52	62.63	129.38	108.67
Overlap	Exclusives	0.04	13.31	12.37	9.69	11.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_3_435 Exclusive	432	432	
ad_gs_25 Exclusive	22	22	
Overlap	3	3