Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_5_68 Exclusive	ad_gs_25	2.08e-01	6.50e-01	5.83e-01	1.29e-01
ad_gs_25 Exclusive	1000run4_3_5_68	7.64e-01	5.86e-02	2.26e-02	3.56e-02
1000run4_3_5_68 Exclusive	ad_gs_25 Exclusive	5.34e-01	7.75e-01	8.66e-01	3.38e-01
ad_gs_25 Exclusive	1000run4_3_5_68 Exclusive	9.81e-01	1.54e-01	4.75e-02	1.26e-01
1000run4_3_5_68 Exclusive	Overlap	2.82e-01	8.93e-01	3.50e-01	2.54e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	5.23e-05
Overlap	Exclusives	2.43e-03	4.93e-04	2.22e-14	1.08e-04



Evaluating how well 1000run4_3_5_68 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_5_68 Exclusive	ad_gs_25	0.63	0.69	0.30	0.15	2.04
ad_gs_25 Exclusive	1000run4_3_5_68	0.57	1.58	2.47	1.78	2.09
1000run4_3_5_68 Exclusive	ad_gs_25 Exclusive	0.60	0.37	-0.00	0.01	1.54
ad_gs_25 Exclusive	1000run4_3_5_68 Exclusive	0.55	0.85	1.64	1.06	1.51
1000run4_3_5_68 Exclusive	Overlap	0.79	1.28	0.88	1.05	1.44
ad_gs_25 Exclusive	Overlap	1.00	3.05	2.22	3.02	3.01
Overlap	Exclusives	0.63	4.65	4.42	2.42	4.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_5_68 Exclusive	ad_gs_25	0.00	0.55	0.24	-0.06	0.02
ad_gs_25 Exclusive	1000run4_3_5_68	0.01	2.70	5.01	4.19	3.94
1000run4_3_5_68 Exclusive	ad_gs_25 Exclusive	0.00	0.04	-0.20	-0.14	0.36
ad_gs_25 Exclusive	1000run4_3_5_68 Exclusive	0.00	-0.24	0.66	-0.04	-0.02
1000run4_3_5_68 Exclusive	Overlap	0.00	1.28	0.52	0.45	0.16
ad_gs_25 Exclusive	Overlap	0.03	101.21	62.64	144.30	17.18
Overlap	Exclusives	0.03	35.95	38.64	29.10	42.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_5_68 Exclusive	65	65	
ad_gs_25 Exclusive	22	22	
Overlap	3	3