Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_4_75 Exclusive	ad_gs_25	2.42e-01	6.64e-01	4.34e-01	1.44e-01
ad_gs_25 Exclusive	1000run4_3_4_75	8.60e-01	7.65e-02	2.53e-02	4.03e-02
1000run4_3_4_75 Exclusive	ad_gs_25 Exclusive	4.25e-01	7.37e-01	6.83e-01	3.20e-01
ad_gs_25 Exclusive	1000run4_3_4_75 Exclusive	8.31e-01	1.01e-01	4.01e-02	1.02e-01
1000run4_3_4_75 Exclusive	Overlap	3.57e-01	9.71e-01	6.49e-01	2.28e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.15e-03	1.01e-03	4.61e-12	7.32e-04



Evaluating how well 1000run4_3_4_75 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_4_75 Exclusive	ad_gs_25	0.62	0.39	0.10	0.27	2.09
ad_gs_25 Exclusive	1000run4_3_4_75	0.56	1.16	2.00	1.69	1.89
1000run4_3_4_75 Exclusive	ad_gs_25 Exclusive	0.60	0.30	0.08	-0.00	1.43
ad_gs_25 Exclusive	1000run4_3_4_75 Exclusive	0.54	0.56	1.94	1.07	1.55
1000run4_3_4_75 Exclusive	Overlap	0.77	1.08	0.50	0.66	1.62
ad_gs_25 Exclusive	Overlap	1.00	2.73	2.24	2.82	3.03
Overlap	Exclusives	0.62	4.16	3.74	2.55	4.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_4_75 Exclusive	ad_gs_25	0.00	0.19	0.01	0.13	0.48
ad_gs_25 Exclusive	1000run4_3_4_75	0.01	1.95	3.54	2.91	3.37
1000run4_3_4_75 Exclusive	ad_gs_25 Exclusive	0.00	-0.01	-0.09	-0.20	0.29
ad_gs_25 Exclusive	1000run4_3_4_75 Exclusive	0.00	-0.34	0.77	-0.06	0.44
1000run4_3_4_75 Exclusive	Overlap	0.00	0.67	0.17	-0.07	0.16
ad_gs_25 Exclusive	Overlap	0.03	67.84	49.86	101.17	33.50
Overlap	Exclusives	0.03	33.20	34.96	29.03	18.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_4_75 Exclusive	72	72	
ad_gs_25 Exclusive	22	22	
Overlap	3	3