Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_3_84 Exclusive	ad_gs_25	4.08e-01	8.48e-01	8.85e-01	2.01e-01
ad_gs_25 Exclusive	1000run4_3_3_84	8.66e-01	1.23e-01	2.47e-02	1.12e-01
1000run4_3_3_84 Exclusive	ad_gs_25 Exclusive	5.23e-01	8.74e-01	8.80e-01	3.46e-01
ad_gs_25 Exclusive	1000run4_3_3_84 Exclusive	7.21e-01	1.74e-01	2.18e-02	1.55e-01
1000run4_3_3_84 Exclusive	Overlap	3.04e-01	9.89e-01	5.75e-01	2.61e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	8.14e-03	9.66e-04	2.49e-13	1.06e-03



Evaluating how well 1000run4_3_3_84 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_3_84 Exclusive	ad_gs_25	0.62	0.54	0.19	-0.05	2.09
ad_gs_25 Exclusive	1000run4_3_3_84	0.55	1.08	1.86	1.59	1.63
1000run4_3_3_84 Exclusive	ad_gs_25 Exclusive	0.60	0.31	0.07	0.11	1.77
ad_gs_25 Exclusive	1000run4_3_3_84 Exclusive	0.53	0.78	1.21	0.97	1.03
1000run4_3_3_84 Exclusive	Overlap	0.76	1.24	0.21	0.73	1.50
ad_gs_25 Exclusive	Overlap	1.00	2.96	2.32	2.52	3.05
Overlap	Exclusives	0.60	4.17	4.25	1.98	3.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_3_84 Exclusive	ad_gs_25	0.00	0.38	0.01	-0.20	1.22
ad_gs_25 Exclusive	1000run4_3_3_84	0.01	1.91	3.48	2.68	2.45
1000run4_3_3_84 Exclusive	ad_gs_25 Exclusive	0.00	0.04	-0.19	-0.13	0.08
ad_gs_25 Exclusive	1000run4_3_3_84 Exclusive	0.00	-0.27	0.41	-0.07	-0.00
1000run4_3_3_84 Exclusive	Overlap	0.00	0.56	-0.11	-0.03	0.46
ad_gs_25 Exclusive	Overlap	0.03	140.39	61.75	131.31	55.57
Overlap	Exclusives	0.03	35.38	37.13	19.18	30.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_3_84 Exclusive	81	81	
ad_gs_25 Exclusive	22	22	
Overlap	3	3