Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_2_98 Exclusive	ad_gs_25	3.59e-01	7.31e-01	6.00e-01	3.78e-01
ad_gs_25 Exclusive	1000run4_3_2_98	8.12e-01	6.26e-02	1.94e-02	1.22e-01
1000run4_3_2_98 Exclusive	ad_gs_25 Exclusive	7.82e-01	8.11e-01	9.60e-01	3.38e-01
ad_gs_25 Exclusive	1000run4_3_2_98 Exclusive	8.41e-01	8.07e-02	2.92e-02	2.37e-01
1000run4_3_2_98 Exclusive	Overlap	1.70e-01	6.67e-01	4.15e-01	1.70e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	9.59e-03	1.96e-03	5.67e-14	2.63e-03



Evaluating how well 1000run4_3_2_98 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_2_98 Exclusive	ad_gs_25	0.61	0.40	-0.00	0.06	2.03
ad_gs_25 Exclusive	1000run4_3_2_98	0.54	1.27	1.56	1.43	1.41
1000run4_3_2_98 Exclusive	ad_gs_25 Exclusive	0.59	0.20	0.10	-0.17	1.58
ad_gs_25 Exclusive	1000run4_3_2_98 Exclusive	0.53	0.98	1.67	0.89	0.75
1000run4_3_2_98 Exclusive	Overlap	0.76	1.30	0.30	0.55	1.40
ad_gs_25 Exclusive	Overlap	1.00	2.87	2.27	3.16	2.91
Overlap	Exclusives	0.60	3.14	3.91	2.06	3.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_2_98 Exclusive	ad_gs_25	0.00	0.26	-0.20	-0.11	-0.05
ad_gs_25 Exclusive	1000run4_3_2_98	0.01	0.73	2.93	1.00	2.38
1000run4_3_2_98 Exclusive	ad_gs_25 Exclusive	0.00	-0.12	-0.37	-0.42	-0.07
ad_gs_25 Exclusive	1000run4_3_2_98 Exclusive	0.01	-0.20	0.96	-0.26	-0.04
1000run4_3_2_98 Exclusive	Overlap	0.00	1.25	0.12	0.09	0.18
ad_gs_25 Exclusive	Overlap	0.03	66.99	83.42	165.57	118.60
Overlap	Exclusives	0.02	30.23	37.06	12.12	24.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_2_98 Exclusive	94	94	
ad_gs_25 Exclusive	22	22	
Overlap	3	3