Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_1_113 Exclusive	ad_gs_25	2.56e-01	8.42e-01	9.35e-01	4.61e-02
ad_gs_25 Exclusive	1000run4_3_1_113	7.35e-01	2.32e-02	4.23e-03	2.26e-02
1000run4_3_1_113 Exclusive	ad_gs_25 Exclusive	2.78e-01	7.85e-01	7.68e-01	9.11e-02
ad_gs_25 Exclusive	1000run4_3_1_113 Exclusive	8.67e-01	3.25e-02	3.27e-03	4.50e-02
1000run4_3_1_113 Exclusive	Overlap	2.48e-01	7.22e-01	4.85e-01	1.81e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.47e-02	3.12e-03	5.45e-16	3.94e-03



Evaluating how well 1000run4_3_1_113 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_1_113 Exclusive	ad_gs_25	0.63	0.90	0.42	0.11	2.21
ad_gs_25 Exclusive	1000run4_3_1_113	0.56	1.82	2.26	1.94	2.17
1000run4_3_1_113 Exclusive	ad_gs_25 Exclusive	0.62	0.74	0.48	0.15	2.10
ad_gs_25 Exclusive	1000run4_3_1_113 Exclusive	0.55	1.50	2.04	1.70	1.61
1000run4_3_1_113 Exclusive	Overlap	0.74	0.86	0.08	0.35	1.37
ad_gs_25 Exclusive	Overlap	1.00	3.32	2.06	2.70	3.08
Overlap	Exclusives	0.59	2.57	4.14	2.08	3.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_1_113 Exclusive	ad_gs_25	0.00	0.36	-0.22	-0.10	0.75
ad_gs_25 Exclusive	1000run4_3_1_113	0.01	0.67	3.30	1.88	1.35
1000run4_3_1_113 Exclusive	ad_gs_25 Exclusive	0.00	0.29	-0.31	-0.23	0.38
ad_gs_25 Exclusive	1000run4_3_1_113 Exclusive	0.01	-0.01	1.30	0.32	0.22
1000run4_3_1_113 Exclusive	Overlap	0.00	1.34	0.17	0.17	0.32
ad_gs_25 Exclusive	Overlap	0.03	87.31	55.99	136.27	140.35
Overlap	Exclusives	0.02	20.93	27.49	9.68	24.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_1_113 Exclusive	110	110	
ad_gs_25 Exclusive	22	22	
Overlap	3	3