Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_3_126 Exclusive	ad_gs_25	4.49e-01	9.86e-01	9.08e-01	8.21e-02
ad_gs_25 Exclusive	1000run4_3_126	6.99e-01	8.66e-02	5.63e-02	6.61e-02
1000run4_3_126 Exclusive	ad_gs_25 Exclusive	5.16e-01	9.93e-01	8.85e-01	2.42e-01
ad_gs_25 Exclusive	1000run4_3_126 Exclusive	6.98e-01	1.64e-01	1.53e-01	1.40e-01
1000run4_3_126 Exclusive	Overlap	3.50e-01	8.57e-01	4.58e-01	1.70e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	2.09e-02	2.40e-03	9.72e-14	2.81e-03



Evaluating how well 1000run4_3_126 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_126 Exclusive	ad_gs_25	0.62	0.63	-0.24	-0.03	2.07
ad_gs_25 Exclusive	1000run4_3_126	0.55	0.71	1.90	0.98	1.81
1000run4_3_126 Exclusive	ad_gs_25 Exclusive	0.60	0.41	-0.07	-0.22	1.40
ad_gs_25 Exclusive	1000run4_3_126 Exclusive	0.54	0.69	1.44	0.61	1.36
1000run4_3_126 Exclusive	Overlap	0.76	1.35	0.27	0.53	1.83
ad_gs_25 Exclusive	Overlap	1.00	3.34	2.21	2.79	2.67
Overlap	Exclusives	0.59	2.75	3.49	2.02	3.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_3_126 Exclusive	ad_gs_25	0.00	0.29	-0.64	-0.27	0.77
ad_gs_25 Exclusive	1000run4_3_126	0.01	1.14	3.18	1.41	1.03
1000run4_3_126 Exclusive	ad_gs_25 Exclusive	0.00	-0.00	-0.69	-0.30	0.27
ad_gs_25 Exclusive	1000run4_3_126 Exclusive	0.01	-0.26	1.13	-0.25	0.16
1000run4_3_126 Exclusive	Overlap	0.00	0.56	0.54	0.98	0.70
ad_gs_25 Exclusive	Overlap	0.03	111.14	64.59	121.61	84.66
Overlap	Exclusives	0.02	22.53	26.95	19.26	14.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_3_126 Exclusive	123	123	
ad_gs_25 Exclusive	22	22	
Overlap	3	3