Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_2_9_146 Exclusive	ad_gs_25	5.14e-04	1.44e-02	1.18e-03	1.00e-04
ad_gs_25 Exclusive	1000run4_2_9_146	8.90e-01	5.74e-02	2.35e-02	1.12e-02
1000run4_2_9_146 Exclusive	ad_gs_25 Exclusive	1.01e-03	1.54e-02	2.39e-03	3.34e-04
ad_gs_25 Exclusive	1000run4_2_9_146 Exclusive	8.66e-01	7.92e-02	1.70e-02	1.94e-02
1000run4_2_9_146 Exclusive	Overlap	2.54e-01	7.31e-01	1.45e-01	4.78e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	2.81e-02	6.40e-03	9.63e-16	2.55e-03



Evaluating how well 1000run4_2_9_146 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_9_146 Exclusive	ad_gs_25	0.77	3.05	3.46	1.93	4.84
ad_gs_25 Exclusive	1000run4_2_9_146	0.56	1.12	2.35	1.70	2.64
1000run4_2_9_146 Exclusive	ad_gs_25 Exclusive	0.75	2.63	3.06	2.07	4.05
ad_gs_25 Exclusive	1000run4_2_9_146 Exclusive	0.55	1.00	2.36	1.49	2.39
1000run4_2_9_146 Exclusive	Overlap	0.87	2.40	1.33	1.74	2.34
ad_gs_25 Exclusive	Overlap	1.00	2.82	2.21	2.97	3.25
Overlap	Exclusives	0.58	2.32	3.05	1.57	3.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_9_146 Exclusive	ad_gs_25	0.00	3.83	2.11	1.39	1.62
ad_gs_25 Exclusive	1000run4_2_9_146	0.01	3.18	4.82	3.93	2.71
1000run4_2_9_146 Exclusive	ad_gs_25 Exclusive	0.00	2.84	1.69	1.61	3.03
ad_gs_25 Exclusive	1000run4_2_9_146 Exclusive	0.01	1.22	3.32	0.98	1.52
1000run4_2_9_146 Exclusive	Overlap	0.00	1.16	0.83	1.05	1.07
ad_gs_25 Exclusive	Overlap	0.03	61.97	57.25	129.58	44.95
Overlap	Exclusives	0.03	26.70	31.61	14.75	18.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_2_9_146 Exclusive	143	143	
ad_gs_25 Exclusive	22	22	
Overlap	3	3