Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_2_8_170 Exclusive	ad_gs_25	2.06e-04	1.92e-03	2.25e-04	8.12e-06
ad_gs_25 Exclusive	1000run4_2_8_170	8.95e-01	3.71e-02	5.28e-03	5.66e-03
1000run4_2_8_170 Exclusive	ad_gs_25 Exclusive	4.42e-04	2.43e-03	3.47e-04	8.74e-05
ad_gs_25 Exclusive	1000run4_2_8_170 Exclusive	7.12e-01	7.49e-02	8.08e-03	5.46e-03
1000run4_2_8_170 Exclusive	Overlap	3.19e-01	4.85e-01	2.89e-01	3.72e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	4.43e-02	2.14e-02	1.23e-16	2.77e-03



Evaluating how well 1000run4_2_8_170 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_8_170 Exclusive	ad_gs_25	0.79	3.10	3.81	3.16	4.33
ad_gs_25 Exclusive	1000run4_2_8_170	0.57	1.63	2.42	1.96	2.88
1000run4_2_8_170 Exclusive	ad_gs_25 Exclusive	0.78	3.25	3.83	2.48	4.60
ad_gs_25 Exclusive	1000run4_2_8_170 Exclusive	0.56	1.04	2.14	1.86	2.57
1000run4_2_8_170 Exclusive	Overlap	0.89	2.07	1.65	1.76	2.08
ad_gs_25 Exclusive	Overlap	1.00	3.15	2.25	2.79	3.10
Overlap	Exclusives	0.58	2.55	3.07	1.98	3.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_8_170 Exclusive	ad_gs_25	0.01	6.44	3.99	3.51	7.92
ad_gs_25 Exclusive	1000run4_2_8_170	0.01	2.67	4.63	3.05	2.49
1000run4_2_8_170 Exclusive	ad_gs_25 Exclusive	0.00	7.43	5.72	3.54	0.48
ad_gs_25 Exclusive	1000run4_2_8_170 Exclusive	0.01	0.64	2.45	2.60	1.83
1000run4_2_8_170 Exclusive	Overlap	0.00	0.32	-0.58	1.09	0.24
ad_gs_25 Exclusive	Overlap	0.03	65.29	82.33	93.72	91.05
Overlap	Exclusives	0.03	27.33	23.32	16.66	19.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_2_8_170 Exclusive	167	167	
ad_gs_25 Exclusive	22	22	
Overlap	3	3