Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_2_6_256 Exclusive	ad_gs_25	6.52e-03	4.38e-03	1.62e-03	1.74e-05
ad_gs_25 Exclusive	1000run4_2_6_256	3.88e-01	1.10e-01	5.05e-03	2.62e-03
1000run4_2_6_256 Exclusive	ad_gs_25 Exclusive	6.22e-03	1.61e-03	1.33e-03	9.11e-05
ad_gs_25 Exclusive	1000run4_2_6_256 Exclusive	2.71e-01	1.46e-01	3.65e-03	2.35e-03
1000run4_2_6_256 Exclusive	Overlap	6.40e-01	7.89e-01	5.57e-01	1.45e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	8.48e-02	6.85e-02	1.96e-24	1.14e-03



Evaluating how well 1000run4_2_6_256 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_6_256 Exclusive	ad_gs_25	0.78	2.74	3.74	2.64	4.92
ad_gs_25 Exclusive	1000run4_2_6_256	0.56	1.36	1.88	1.47	3.17
1000run4_2_6_256 Exclusive	ad_gs_25 Exclusive	0.77	2.43	3.80	2.49	4.15
ad_gs_25 Exclusive	1000run4_2_6_256 Exclusive	0.55	0.93	1.51	1.43	2.59
1000run4_2_6_256 Exclusive	Overlap	0.86	1.98	1.12	1.40	1.90
ad_gs_25 Exclusive	Overlap	1.00	2.81	2.21	3.12	2.83
Overlap	Exclusives	0.58	2.54	2.97	1.73	4.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_6_256 Exclusive	ad_gs_25	0.00	4.37	4.19	3.88	8.38
ad_gs_25 Exclusive	1000run4_2_6_256	0.02	2.15	3.59	3.89	4.43
1000run4_2_6_256 Exclusive	ad_gs_25 Exclusive	0.00	3.40	5.28	3.72	2.43
ad_gs_25 Exclusive	1000run4_2_6_256 Exclusive	0.02	0.78	1.79	1.75	3.14
1000run4_2_6_256 Exclusive	Overlap	0.00	1.35	2.87	2.59	7.50
ad_gs_25 Exclusive	Overlap	0.03	61.77	72.23	210.52	51.07
Overlap	Exclusives	0.03	18.49	17.35	11.22	16.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_2_6_256 Exclusive	253	253	
ad_gs_25 Exclusive	22	22	
Overlap	3	3