Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 1000run4_2_3_442 Exclusive ad_gs_25 9.63e-05 2.14e-04 3.93e-06 2.75e-08 ad_gs_25 Exclusive 1000run4_2_3_442 1.73e-01 1.31e-01 4.52e-05 4.59e-05 1000run4_2_3_442 Exclusive ad_gs_25 Exclusive 1.70e-04 2.37e-04 7.29e-06 2.94e-07 ad_gs_25 Exclusive 1000run4_2_3_442 Exclusive 1.43e-01 1.62e-01 1.12e-05 8.63e-05 1000run4_2_3_442 Exclusive Overlap 3.50e-01 6.67e-01 2.48e-01 1.99e-02 ad_gs_25 Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-07 Overlap Exclusives 1.84e-01 7.39e-02 2.85e-40 5.22e-07 Evaluating how well 1000run4_2_3_442 genes are linked to ad_gs_25 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 1000run4_2_3_442 Exclusive ad_gs_25 0.84 4.09 5.41 3.70 6.35 ad_gs_25 Exclusive 1000run4_2_3_442 0.56 1.63 2.28 2.20 5.31 1000run4_2_3_442 Exclusive ad_gs_25 Exclusive 0.83 4.36 5.35 3.15 5.70 ad_gs_25 Exclusive 1000run4_2_3_442 Exclusive 0.56 1.50 2.15 1.74 4.49 1000run4_2_3_442 Exclusive Overlap 0.89 2.06 1.10 1.87 2.35 ad_gs_25 Exclusive Overlap 1.00 3.32 2.14 2.84 3.03 Overlap Exclusives 0.58 2.21 2.78 1.75 4.94 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 1000run4_2_3_442 Exclusive ad_gs_25 0.01 9.08 11.98 7.53 14.91 ad_gs_25 Exclusive 1000run4_2_3_442 0.03 4.04 5.19 5.78 7.07 1000run4_2_3_442 Exclusive ad_gs_25 Exclusive 0.01 9.10 12.14 8.24 4.62 ad_gs_25 Exclusive 1000run4_2_3_442 Exclusive 0.03 2.94 3.89 3.27 4.82 1000run4_2_3_442 Exclusive Overlap 0.00 2.20 11.94 3.91 12.26 ad_gs_25 Exclusive Overlap 0.03 85.15 58.26 152.81 131.43 Overlap Exclusives 0.04 12.72 11.86 8.55 13.63 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 1000run4_2_3_442 Exclusive 439 439 ad_gs_25 Exclusive 22 22 Overlap 3 3