Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_2_1_699 Exclusive	ad_gs_25	1.61e-02	1.53e-02	9.23e-04	6.83e-06
ad_gs_25 Exclusive	1000run4_2_1_699	6.89e-02	4.73e-02	5.41e-07	1.90e-06
1000run4_2_1_699 Exclusive	ad_gs_25 Exclusive	2.68e-02	1.51e-02	8.94e-04	2.13e-05
ad_gs_25 Exclusive	1000run4_2_1_699 Exclusive	6.17e-02	7.92e-02	3.32e-08	7.74e-06
1000run4_2_1_699 Exclusive	Overlap	8.57e-01	7.89e-01	5.94e-01	1.41e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	5.29e-01	6.95e-02	7.49e-66	9.90e-07



Evaluating how well 1000run4_2_1_699 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_1_699 Exclusive	ad_gs_25	0.81	3.53	4.60	3.13	5.46
ad_gs_25 Exclusive	1000run4_2_1_699	0.55	2.00	2.35	1.72	4.46
1000run4_2_1_699 Exclusive	ad_gs_25 Exclusive	0.80	3.27	4.43	3.52	4.65
ad_gs_25 Exclusive	1000run4_2_1_699 Exclusive	0.55	1.85	2.21	1.86	4.56
1000run4_2_1_699 Exclusive	Overlap	0.84	1.32	0.42	1.29	1.87
ad_gs_25 Exclusive	Overlap	1.00	2.97	1.94	2.83	2.98
Overlap	Exclusives	0.56	1.79	3.25	1.53	6.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_1_699 Exclusive	ad_gs_25	0.00	3.38	6.37	3.66	6.60
ad_gs_25 Exclusive	1000run4_2_1_699	0.04	3.17	3.53	2.89	5.24
1000run4_2_1_699 Exclusive	ad_gs_25 Exclusive	0.00	4.88	7.16	4.34	4.76
ad_gs_25 Exclusive	1000run4_2_1_699 Exclusive	0.04	2.55	2.81	2.69	4.47
1000run4_2_1_699 Exclusive	Overlap	0.00	0.79	2.80	1.13	-0.05
ad_gs_25 Exclusive	Overlap	0.03	109.59	68.77	131.16	96.06
Overlap	Exclusives	0.05	7.28	7.74	4.65	10.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_2_1_699 Exclusive	696	694	STON1-GTF2A1L;PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3