Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_2_845 Exclusive	ad_gs_25	4.61e-02	6.26e-02	2.57e-03	3.71e-05
ad_gs_25 Exclusive	1000run4_2_845	3.73e-02	3.85e-02	3.23e-09	2.77e-07
1000run4_2_845 Exclusive	ad_gs_25 Exclusive	4.96e-02	5.38e-02	1.87e-03	1.60e-04
ad_gs_25 Exclusive	1000run4_2_845 Exclusive	1.54e-02	4.69e-02	2.20e-08	1.27e-06
1000run4_2_845 Exclusive	Overlap	9.83e-01	7.89e-01	8.25e-01	2.68e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.60e-01	8.38e-02	4.82e-75	4.26e-07



Evaluating how well 1000run4_2_845 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_845 Exclusive	ad_gs_25	0.78	2.50	3.41	2.51	5.29
ad_gs_25 Exclusive	1000run4_2_845	0.55	1.62	2.12	1.61	4.81
1000run4_2_845 Exclusive	ad_gs_25 Exclusive	0.77	2.38	2.95	2.45	4.47
ad_gs_25 Exclusive	1000run4_2_845 Exclusive	0.55	1.16	2.11	1.33	4.75
1000run4_2_845 Exclusive	Overlap	0.80	0.51	0.19	0.71	1.71
ad_gs_25 Exclusive	Overlap	1.00	2.72	2.18	3.44	3.15
Overlap	Exclusives	0.55	1.38	2.10	1.20	5.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_2_845 Exclusive	ad_gs_25	0.00	2.45	4.88	2.49	0.59
ad_gs_25 Exclusive	1000run4_2_845	0.05	2.00	2.85	2.69	5.17
1000run4_2_845 Exclusive	ad_gs_25 Exclusive	0.00	2.20	4.50	2.95	4.82
ad_gs_25 Exclusive	1000run4_2_845 Exclusive	0.05	1.08	2.21	1.77	5.11
1000run4_2_845 Exclusive	Overlap	0.00	0.25	4.20	1.07	0.58
ad_gs_25 Exclusive	Overlap	0.03	103.52	75.05	181.80	59.73
Overlap	Exclusives	0.06	5.81	5.27	3.83	6.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_2_845 Exclusive	842	839	STON1-GTF2A1L;C19orf84;PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3