Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_1_5_2104 Exclusive	ad_gs_25	2.77e-01	2.67e-01	2.10e-02	4.33e-04
ad_gs_25 Exclusive	1000run4_1_5_2104	1.89e-05	2.77e-02	3.52e-14	4.56e-12
1000run4_1_5_2104 Exclusive	ad_gs_25 Exclusive	3.83e-01	3.62e-01	5.61e-02	1.57e-02
ad_gs_25 Exclusive	1000run4_1_5_2104 Exclusive	2.36e-06	5.49e-02	2.98e-14	1.06e-11
1000run4_1_5_2104 Exclusive	Overlap	8.18e-01	6.09e-01	1.59e-01	6.76e-03
ad_gs_25 Exclusive	Overlap	7.45e-12	7.45e-12	7.45e-12	7.45e-12
Overlap	Exclusives	4.33e-03	1.86e-02	2.44e-173	7.81e-15



Evaluating how well 1000run4_1_5_2104 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_1_5_2104 Exclusive	ad_gs_25	0.73	1.14	1.86	1.42	3.49
ad_gs_25 Exclusive	1000run4_1_5_2104	0.55	1.03	2.72	1.13	7.53
1000run4_1_5_2104 Exclusive	ad_gs_25 Exclusive	0.70	1.30	1.79	1.24	3.34
ad_gs_25 Exclusive	1000run4_1_5_2104 Exclusive	0.55	0.89	2.20	1.35	7.01
1000run4_1_5_2104 Exclusive	Overlap	0.86	0.47	0.20	0.92	2.59
ad_gs_25 Exclusive	Overlap	1.00	4.04	3.61	3.24	4.06
Overlap	Exclusives	0.55	2.28	3.63	1.31	8.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_1_5_2104 Exclusive	ad_gs_25	0.00	1.68	2.69	1.92	4.08
ad_gs_25 Exclusive	1000run4_1_5_2104	0.12	1.36	2.68	1.56	6.00
1000run4_1_5_2104 Exclusive	ad_gs_25 Exclusive	0.00	1.46	2.56	1.81	1.86
ad_gs_25 Exclusive	1000run4_1_5_2104 Exclusive	0.12	0.77	1.44	1.58	5.00
1000run4_1_5_2104 Exclusive	Overlap	0.00	0.30	0.15	1.49	7.55
ad_gs_25 Exclusive	Overlap	0.06	158.00	115.13	283.29	356.96
Overlap	Exclusives	0.13	3.84	5.00	2.32	8.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_1_5_2104 Exclusive	2095	2083	PTGES3L-AARSD1;C19orf84;CROCC2;C3orf49;PRAMEF11;FAM47E-STBD1;RPL17-C18orf32;STON1-GTF2A1L;MFRP;UGT2A1;CORO7-PAM16;RBAK-RBAKDN
ad_gs_25 Exclusive	20	20	
Overlap	5	5