Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_1_4585 Exclusive	ad_gs_25	5.83e-01	7.08e-01	8.82e-02	2.65e-04
ad_gs_25 Exclusive	1000run4_1_4585	3.69e-05	8.24e-03	1.54e-83	8.48e-27
1000run4_1_4585 Exclusive	ad_gs_25 Exclusive	9.31e-01	6.56e-01	2.51e-01	1.05e-02
ad_gs_25 Exclusive	1000run4_1_4585 Exclusive	1.52e-04	1.59e-02	2.47e-80	1.48e-25
1000run4_1_4585 Exclusive	Overlap	2.44e-01	7.45e-01	1.14e-01	8.80e-03
ad_gs_25 Exclusive	Overlap	1.16e-08	2.53e-08	1.16e-08	2.35e-08
Overlap	Exclusives	1.83e-16	3.81e-03	1.48e-120	1.38e-30



Evaluating how well 1000run4_1_4585 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_1_4585 Exclusive	ad_gs_25	0.74	3.05	2.17	2.87	4.28
ad_gs_25 Exclusive	1000run4_1_4585	0.55	1.12	4.61	1.23	11.18
1000run4_1_4585 Exclusive	ad_gs_25 Exclusive	0.73	1.74	1.44	1.87	3.31
ad_gs_25 Exclusive	1000run4_1_4585 Exclusive	0.55	1.19	4.17	1.07	13.73
1000run4_1_4585 Exclusive	Overlap	0.77	3.67	1.76	3.37	2.55
ad_gs_25 Exclusive	Overlap	0.97	4.55	5.33	4.26	4.88
Overlap	Exclusives	0.55	2.25	5.86	1.36	15.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_1_4585 Exclusive	ad_gs_25	0.00	3.71	3.25	2.93	5.65
ad_gs_25 Exclusive	1000run4_1_4585	0.26	1.36	4.37	1.65	8.85
1000run4_1_4585 Exclusive	ad_gs_25 Exclusive	0.00	2.60	1.86	2.24	1.29
ad_gs_25 Exclusive	1000run4_1_4585 Exclusive	0.25	0.93	3.04	1.07	9.18
1000run4_1_4585 Exclusive	Overlap	0.00	5.63	2.51	5.66	4.85
ad_gs_25 Exclusive	Overlap	0.15	267.14	407.27	331.31	187.56
Overlap	Exclusives	0.26	3.45	7.07	2.24	14.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_1_4585 Exclusive	4567	4543	PTGES3L-AARSD1;C8orf89;CYP3A7-CYP3A51P;IQCJ-SCHIP1;ZHX1-C8orf76;RFX1;MYO15B;FXYD6-FXYD2;CROCC2;C3orf49;CORO7-PAM16;STON1-GTF2A1L;FAM47E-STBD1;UGT2A1;PRR36;C19orf84;NPIPB6;MFRP;JMJD7-PLA2G4B;RBAK-RBAKDN;PRAMEF11;RPL17-C18orf32;TUBA4B;RPS10-NUDT3
ad_gs_25 Exclusive	16	16	
Overlap	9	9