Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run4_0_5_8693 Exclusive	ad_gs_25	8.55e-02	5.37e-01	4.41e-02	1.02e-04
ad_gs_25 Exclusive	1000run4_0_5_8693	3.19e-07	4.00e-09	8.74e-217	8.54e-99
1000run4_0_5_8693 Exclusive	ad_gs_25 Exclusive	4.39e-01	5.75e-01	1.52e-01	1.37e-02
ad_gs_25 Exclusive	1000run4_0_5_8693 Exclusive	5.13e-06	6.95e-09	3.01e-154	1.64e-98
1000run4_0_5_8693 Exclusive	Overlap	1.02e-01	8.57e-01	6.35e-02	3.10e-03
ad_gs_25 Exclusive	Overlap	7.60e-10	2.21e-11	4.06e-11	9.22e-11
Overlap	Exclusives	5.41e-37	5.19e-10	1.71e-229	6.04e-98



Evaluating how well 1000run4_0_5_8693 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_0_5_8693 Exclusive	ad_gs_25	0.75	6.71	2.03	9.84	4.91
ad_gs_25 Exclusive	1000run4_0_5_8693	0.57	2.14	18.52	1.72	45.60
1000run4_0_5_8693 Exclusive	ad_gs_25 Exclusive	0.75	5.49	1.73	7.84	2.68
ad_gs_25 Exclusive	1000run4_0_5_8693 Exclusive	0.57	1.84	16.99	1.57	43.57
1000run4_0_5_8693 Exclusive	Overlap	0.75	6.48	0.98	10.17	3.48
ad_gs_25 Exclusive	Overlap	0.96	4.22	6.26	4.02	6.21
Overlap	Exclusives	0.57	2.21	22.92	1.91	49.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run4_0_5_8693 Exclusive	ad_gs_25	0.01	15.02	2.73	16.86	3.68
ad_gs_25 Exclusive	1000run4_0_5_8693	0.49	2.13	27.64	2.01	36.45
1000run4_0_5_8693 Exclusive	ad_gs_25 Exclusive	0.00	13.52	3.09	14.51	1.47
ad_gs_25 Exclusive	1000run4_0_5_8693 Exclusive	0.48	1.59	25.65	1.65	32.06
1000run4_0_5_8693 Exclusive	Overlap	0.00	12.44	0.40	16.32	0.22
ad_gs_25 Exclusive	Overlap	0.14	182.00	589.21	248.14	322.53
Overlap	Exclusives	0.49	2.08	32.21	2.16	39.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run4_0_5_8693 Exclusive	8655	8610	RFX1;C3orf49;C8orf89;RPS10-NUDT3;ABHD14A-ACY1;PRAMEF11;GSG1L2;FXYD6-FXYD2;MUC2;ZHX1-C8orf76;RPL17-C18orf32;PAK6;IQCJ-SCHIP1;DNAJC25-GNG10;PRR36;CROCC2;RNF103-CHMP3;FAM205C;CCDC7;TNFSF12-TNFSF13;RBAK-RBAKDN;FPGT-TNNI3K;MFRP;CCDC188;MSANTD3-TMEFF1;UGT2A1;TUBA4B;C19orf84;PTGES3L-AARSD1;CYP3A7-CYP3A51P;MYO15B;TFDP2;CORO7-PAM16;RFPL2;JMJD7-PLA2G4B;ZNF559-ZNF177;TTC6;SHANK3;STON1-GTF2A1L;TVP23C-CDRT4;ANKHD1-EIF4EBP3;FAM47E-STBD1;EPPIN-WFDC6;RPL41;NPIPB6
ad_gs_25 Exclusive	11	11	
Overlap	14	14