Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
random_exp Exclusive	ad_gs_25	6.53e-02	5.15e-02	1.95e-03	5.95e-05
ad_gs_25 Exclusive	random_exp	4.94e-03	1.28e-02	4.29e-13	1.85e-11
random_exp Exclusive	ad_gs_25 Exclusive	1.00e-01	5.34e-02	4.88e-03	1.82e-03
ad_gs_25 Exclusive	random_exp Exclusive	5.78e-03	8.25e-03	2.48e-13	5.64e-11
random_exp Exclusive	Overlap	9.12e-01	7.85e-01	3.70e-01	3.86e-02
ad_gs_25 Exclusive	Overlap	9.14e-09	1.83e-09	1.83e-09	2.30e-07
Overlap	Exclusives	2.97e-02	1.02e-01	3.54e-117	1.71e-10



Evaluating how well random_exp genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
random_exp Exclusive	ad_gs_25	0.76	2.29	2.61	2.05	4.00
ad_gs_25 Exclusive	random_exp	0.55	1.91	3.37	1.89	7.13
random_exp Exclusive	ad_gs_25 Exclusive	0.74	2.12	2.92	2.08	3.94
ad_gs_25 Exclusive	random_exp Exclusive	0.55	1.94	2.93	2.10	6.19
random_exp Exclusive	Overlap	0.84	0.51	0.19	0.98	2.39
ad_gs_25 Exclusive	Overlap	1.00	3.25	2.59	3.45	3.01
Overlap	Exclusives	0.56	2.17	2.94	1.23	6.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
random_exp Exclusive	ad_gs_25	0.00	2.78	4.51	3.08	3.36
ad_gs_25 Exclusive	random_exp	0.08	2.37	2.86	2.61	6.33
random_exp Exclusive	ad_gs_25 Exclusive	0.00	3.67	5.09	3.62	4.53
ad_gs_25 Exclusive	random_exp Exclusive	0.08	1.60	2.29	2.32	4.88
random_exp Exclusive	Overlap	0.00	0.53	3.21	1.41	5.16
ad_gs_25 Exclusive	Overlap	0.05	114.42	77.47	131.48	62.96
Overlap	Exclusives	0.08	5.64	4.51	2.68	8.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
random_exp Exclusive	1293	1288	MFRP;C19orf84;PTGES3L-AARSD1;STON1-GTF2A1L;UGT2A1
ad_gs_25 Exclusive	21	21	
Overlap	4	4