Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice Exclusive	eqtl	6.09e-01	9.22e-01	1.54e-01	4.84e-01
eqtl Exclusive	splice	5.89e-01	3.49e-01	2.20e-01	9.23e-02
splice Exclusive	eqtl Exclusive	3.75e-01	8.25e-01	1.40e-01	4.39e-01
eqtl Exclusive	splice Exclusive	8.38e-01	6.25e-01	2.93e-01	3.17e-01
splice Exclusive	Overlap	8.44e-01	9.34e-01	9.87e-01	8.27e-01
eqtl Exclusive	Overlap	2.23e-01	1.83e-01	6.27e-02	2.16e-02
Overlap	Exclusives	7.21e-01	3.07e-01	2.31e-17	9.65e-03



Evaluating how well splice genes are linked to eqtl genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice Exclusive	eqtl	0.54	0.27	-0.11	0.21	1.21
eqtl Exclusive	splice	0.55	0.32	1.46	0.43	2.22
splice Exclusive	eqtl Exclusive	0.53	0.28	-0.08	0.22	0.97
eqtl Exclusive	splice Exclusive	0.54	0.15	1.07	0.38	1.43
splice Exclusive	Overlap	0.61	-0.72	-0.70	-0.43	0.73
eqtl Exclusive	Overlap	0.76	1.44	1.47	1.53	2.46
Overlap	Exclusives	0.56	1.15	1.71	1.66	2.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice Exclusive	eqtl	0.01	0.20	0.16	-0.10	1.05
eqtl Exclusive	splice	0.01	0.29	1.81	0.43	2.65
splice Exclusive	eqtl Exclusive	0.01	0.22	0.07	-0.03	0.65
eqtl Exclusive	splice Exclusive	0.01	-0.22	0.81	-0.04	0.62
splice Exclusive	Overlap	0.00	-0.65	-0.87	-0.34	-0.10
eqtl Exclusive	Overlap	0.00	1.98	10.46	11.54	13.51
Overlap	Exclusives	0.02	0.89	0.92	1.51	1.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice Exclusive	137	137	
eqtl Exclusive	115	114	CLEC20A
Overlap	7	7