Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eqtl Exclusive	ea	7.20e-01	5.92e-01	9.26e-01	3.07e-01
ea Exclusive	eqtl	5.48e-01	7.10e-01	3.76e-01	1.67e-01
eqtl Exclusive	ea Exclusive	6.18e-01	4.48e-01	9.94e-01	1.53e-01
ea Exclusive	eqtl Exclusive	5.05e-01	7.60e-01	4.63e-01	2.64e-01
eqtl Exclusive	Overlap	6.10e-01	2.20e-01	2.84e-01	7.89e-02
ea Exclusive	Overlap	9.84e-01	9.78e-01	9.80e-01	4.68e-01
Overlap	Exclusives	1.83e-01	9.31e-01	3.71e-09	2.61e-01



Evaluating how well eqtl genes are linked to ea genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl Exclusive	ea	0.48	-1.30	-1.04	-1.03	-1.10
ea Exclusive	eqtl	0.53	-0.70	-0.58	-0.26	1.01
eqtl Exclusive	ea Exclusive	0.47	-1.39	-1.19	-1.15	-1.44
ea Exclusive	eqtl Exclusive	0.52	-0.65	-0.25	-0.31	0.71
eqtl Exclusive	Overlap	0.69	0.48	1.26	0.85	1.69
ea Exclusive	Overlap	0.62	0.04	-0.29	0.17	0.97
Overlap	Exclusives	0.53	0.79	0.37	1.05	1.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl Exclusive	ea	0.01	-0.34	-0.82	-0.42	-0.60
ea Exclusive	eqtl	0.01	-1.31	-0.50	-1.34	-0.24
eqtl Exclusive	ea Exclusive	0.01	-0.65	-1.01	-0.79	-0.78
ea Exclusive	eqtl Exclusive	0.01	-1.26	-0.43	-0.79	-0.41
eqtl Exclusive	Overlap	0.00	2.35	8.25	5.75	2.70
ea Exclusive	Overlap	0.00	-0.35	-0.40	-0.33	-0.02
Overlap	Exclusives	0.01	1.35	0.84	0.86	1.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eqtl Exclusive	115	114	CLEC20A
ea Exclusive	136	135	CHURC1-FNTB
Overlap	7	7