Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
17_difference_genes	ad_gs_25	2.38e-07	2.88e-09	1.17e-09	3.07e-11
ad_gs_25	17_difference_genes	8.29e-01	2.22e-01	1.15e-01	2.87e-02



Evaluating how well 17_difference_genes genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
17_difference_genes	ad_gs_25	0.87	3.68	7.90	3.71	6.00
ad_gs_25	17_difference_genes	0.63	2.06	1.59	1.64	1.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
17_difference_genes	ad_gs_25	0.04	27.11	119.61	40.39	68.14
ad_gs_25	17_difference_genes	0.01	50.40	15.65	26.21	45.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
17_difference_genes	17	17	
ad_gs_25	25	25