Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_zscore_3_144 Exclusive	ad_gs_25	4.37e-01	6.81e-01	6.84e-01	1.79e-01
ad_gs_25 Exclusive	data_diff_zscore_3_144	5.70e-01	1.02e-01	3.11e-02	3.65e-02
data_diff_zscore_3_144 Exclusive	ad_gs_25 Exclusive	8.45e-01	8.01e-01	9.57e-01	2.92e-01
ad_gs_25 Exclusive	data_diff_zscore_3_144 Exclusive	4.83e-01	1.11e-01	1.49e-01	8.87e-02
data_diff_zscore_3_144 Exclusive	Overlap	4.24e-01	7.04e-01	3.57e-01	1.15e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.59e-02	1.12e-02	3.53e-14	5.47e-03



Evaluating how well data_diff_zscore_3_144 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_zscore_3_144 Exclusive	ad_gs_25	0.62	0.63	-0.52	-0.09	2.07
ad_gs_25 Exclusive	data_diff_zscore_3_144	0.56	0.60	1.61	0.98	2.51
data_diff_zscore_3_144 Exclusive	ad_gs_25 Exclusive	0.60	0.20	-0.54	-0.29	1.20
ad_gs_25 Exclusive	data_diff_zscore_3_144 Exclusive	0.55	0.24	1.53	0.52	2.03
data_diff_zscore_3_144 Exclusive	Overlap	0.75	0.99	-0.09	0.33	1.64
ad_gs_25 Exclusive	Overlap	1.00	2.94	1.88	2.75	3.13
Overlap	Exclusives	0.58	2.48	3.06	1.70	4.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_zscore_3_144 Exclusive	ad_gs_25	0.00	0.25	-0.66	-0.26	0.63
ad_gs_25 Exclusive	data_diff_zscore_3_144	0.01	0.88	2.50	1.31	1.69
data_diff_zscore_3_144 Exclusive	ad_gs_25 Exclusive	0.00	-0.06	-0.74	-0.37	0.05
ad_gs_25 Exclusive	data_diff_zscore_3_144 Exclusive	0.01	-0.55	0.82	-0.18	0.57
data_diff_zscore_3_144 Exclusive	Overlap	0.00	0.20	0.25	0.13	1.41
ad_gs_25 Exclusive	Overlap	0.03	62.98	65.36	141.39	48.33
Overlap	Exclusives	0.02	17.00	19.77	10.37	15.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_zscore_3_144 Exclusive	141	141	
ad_gs_25 Exclusive	22	22	
Overlap	3	3