Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_zscore_2_9_161 Exclusive	ad_gs_25	6.31e-05	1.75e-03	1.25e-04	7.78e-06
ad_gs_25 Exclusive	data_diff_zscore_2_9_161	8.03e-01	1.22e-01	8.05e-03	3.17e-03
data_diff_zscore_2_9_161 Exclusive	ad_gs_25 Exclusive	7.41e-05	2.95e-03	2.92e-04	2.38e-05
ad_gs_25 Exclusive	data_diff_zscore_2_9_161 Exclusive	5.89e-01	1.02e-01	2.55e-02	5.75e-03
data_diff_zscore_2_9_161 Exclusive	Overlap	2.41e-01	4.58e-01	2.41e-01	5.29e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.30e-02	7.61e-03	4.87e-16	1.59e-03



Evaluating how well data_diff_zscore_2_9_161 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_zscore_2_9_161 Exclusive	ad_gs_25	0.79	3.47	4.22	2.35	5.68
ad_gs_25 Exclusive	data_diff_zscore_2_9_161	0.57	1.11	2.14	1.62	2.88
data_diff_zscore_2_9_161 Exclusive	ad_gs_25 Exclusive	0.78	2.89	4.15	2.09	4.94
ad_gs_25 Exclusive	data_diff_zscore_2_9_161 Exclusive	0.56	0.81	2.18	1.29	2.73
data_diff_zscore_2_9_161 Exclusive	Overlap	0.89	2.00	1.64	1.66	2.11
ad_gs_25 Exclusive	Overlap	1.00	2.55	2.07	2.45	2.96
Overlap	Exclusives	0.59	1.97	3.33	1.80	3.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_zscore_2_9_161 Exclusive	ad_gs_25	0.00	7.04	6.70	2.95	8.76
ad_gs_25 Exclusive	data_diff_zscore_2_9_161	0.01	3.82	5.15	4.92	3.31
data_diff_zscore_2_9_161 Exclusive	ad_gs_25 Exclusive	0.00	6.11	4.94	3.34	8.54
ad_gs_25 Exclusive	data_diff_zscore_2_9_161 Exclusive	0.01	1.03	3.77	2.32	2.23
data_diff_zscore_2_9_161 Exclusive	Overlap	0.00	0.40	1.38	0.86	1.72
ad_gs_25 Exclusive	Overlap	0.03	78.06	48.50	105.04	40.06
Overlap	Exclusives	0.03	24.44	30.45	14.26	20.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_zscore_2_9_161 Exclusive	158	158	
ad_gs_25 Exclusive	22	22	
Overlap	3	3