Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_SLC44A1_16	ad_gs_25	6.34e-08	1.20e-09	4.73e-10	1.15e-11
ad_gs_25	data_diff_SLC44A1_16	7.81e-01	3.47e-01	1.42e-01	5.87e-02



Evaluating how well data_diff_SLC44A1_16 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SLC44A1_16	ad_gs_25	0.88	4.86	7.09	3.84	6.00
ad_gs_25	data_diff_SLC44A1_16	0.64	1.82	1.22	1.75	1.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SLC44A1_16	ad_gs_25	0.04	69.46	113.79	51.09	69.47
ad_gs_25	data_diff_SLC44A1_16	0.02	20.77	20.69	55.48	45.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_SLC44A1_16	16	16	
ad_gs_25	25	25