Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_GAS2	ad_gs_25	3.24e-08	3.65e-09	1.49e-10	4.32e-11
ad_gs_25	data_diff_GAS2	5.97e-01	2.89e-01	1.54e-01	4.14e-02



Evaluating how well data_diff_GAS2 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GAS2	ad_gs_25	0.88	4.05	6.23	3.65	6.48
ad_gs_25	data_diff_GAS2	0.63	1.36	1.33	1.44	1.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GAS2	ad_gs_25	0.04	29.60	99.96	49.00	44.87
ad_gs_25	data_diff_GAS2	0.02	32.83	21.72	60.77	33.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_GAS2	16	16	
ad_gs_25	25	25