Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_RAB11FIP4	ad_gs_25	8.48e-08	1.28e-09	1.99e-10	1.43e-11
ad_gs_25	data_diff_RAB11FIP4	8.85e-01	3.19e-01	2.08e-01	7.09e-02



Evaluating how well data_diff_RAB11FIP4 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_RAB11FIP4	ad_gs_25	0.88	3.25	7.89	3.99	6.20
ad_gs_25	data_diff_RAB11FIP4	0.64	1.77	1.57	1.78	2.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_RAB11FIP4	ad_gs_25	0.04	13.68	103.59	15.84	53.29
ad_gs_25	data_diff_RAB11FIP4	0.02	43.59	17.86	39.35	8.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_RAB11FIP4	16	16	
ad_gs_25	25	25