Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_SIN3B	ad_gs_25	5.37e-10	6.89e-10	1.35e-10	2.25e-11
ad_gs_25	data_diff_SIN3B	8.16e-01	1.47e-01	4.64e-02	3.69e-02



Evaluating how well data_diff_SIN3B genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SIN3B	ad_gs_25	0.88	5.06	7.77	3.93	7.72
ad_gs_25	data_diff_SIN3B	0.64	2.16	1.96	1.85	2.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SIN3B	ad_gs_25	0.04	74.87	103.95	37.20	8.91
ad_gs_25	data_diff_SIN3B	0.02	44.69	26.65	65.23	39.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_SIN3B	16	16	
ad_gs_25	25	25