Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_CAPN2	ad_gs_25	3.15e-08	3.54e-09	5.37e-10	5.67e-11
ad_gs_25	data_diff_CAPN2	7.96e-01	2.49e-01	1.39e-01	9.90e-02



Evaluating how well data_diff_CAPN2 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CAPN2	ad_gs_25	0.87	4.09	6.92	4.29	6.19
ad_gs_25	data_diff_CAPN2	0.62	1.63	1.36	1.35	1.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CAPN2	ad_gs_25	0.04	67.07	112.35	8.37	108.62
ad_gs_25	data_diff_CAPN2	0.02	53.63	24.12	36.10	41.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_CAPN2	16	16	
ad_gs_25	25	25