Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_SSC4D	GeneGroup2	4.99e-08	2.41e-09	1.87e-10	6.06e-11
GeneGroup2	data_diff_SSC4D	7.77e-01	2.36e-01	7.27e-02	1.83e-02



Evaluating how well data_diff_SSC4D genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SSC4D	GeneGroup2	0.88	3.86	6.69	4.37	5.80
GeneGroup2	data_diff_SSC4D	0.67	1.64	1.40	1.87	2.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SSC4D	GeneGroup2	0.05	96.62	132.52	103.70	11.91
GeneGroup2	data_diff_SSC4D	0.02	45.86	43.58	16.05	21.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_SSC4D	16	16	
GeneGroup2	25	25