Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_MS4A4E	ad_gs_25	1.82e-05	6.55e-07	2.67e-08	5.04e-09
ad_gs_25	data_diff_MS4A4E	4.52e-01	6.47e-01	2.08e-01	6.81e-02



Evaluating how well data_diff_MS4A4E genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_MS4A4E	ad_gs_25	0.81	1.87	5.29	2.52	6.26
ad_gs_25	data_diff_MS4A4E	0.61	0.62	0.32	0.62	1.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_MS4A4E	ad_gs_25	0.00	0.57	6.48	2.45	9.76
ad_gs_25	data_diff_MS4A4E	0.00	6.94	2.14	3.47	0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_MS4A4E	16	16	
ad_gs_25	25	25