Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_TIAM2	ad_gs_25	1.46e-07	3.51e-08	8.84e-10	1.30e-10
ad_gs_25	data_diff_TIAM2	7.85e-01	3.10e-01	1.89e-01	6.45e-02



Evaluating how well data_diff_TIAM2 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_TIAM2	ad_gs_25	0.88	3.57	6.21	4.26	7.24
ad_gs_25	data_diff_TIAM2	0.63	1.48	1.40	1.46	1.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_TIAM2	ad_gs_25	0.04	71.32	104.39	43.09	47.69
ad_gs_25	data_diff_TIAM2	0.02	40.89	10.71	8.07	2.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_TIAM2	16	16	
ad_gs_25	25	25