Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_GALNT13	ad_gs_25	6.09e-07	5.26e-08	4.62e-09	8.31e-10
ad_gs_25	data_diff_GALNT13	5.51e-01	4.15e-01	1.22e-01	7.27e-02



Evaluating how well data_diff_GALNT13 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GALNT13	ad_gs_25	0.87	3.88	6.98	3.03	6.44
ad_gs_25	data_diff_GALNT13	0.63	1.49	1.01	1.86	2.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GALNT13	ad_gs_25	0.04	58.54	119.43	20.61	52.90
ad_gs_25	data_diff_GALNT13	0.02	42.92	16.30	20.78	16.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_GALNT13	16	16	
ad_gs_25	25	25