Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_CDH3	ad_gs_25	1.03e-06	3.33e-08	1.87e-08	8.31e-10
ad_gs_25	data_diff_CDH3	8.30e-01	2.89e-01	1.44e-01	4.08e-02



Evaluating how well data_diff_CDH3 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CDH3	ad_gs_25	0.87	3.95	6.61	3.32	6.34
ad_gs_25	data_diff_CDH3	0.62	1.56	1.03	1.07	1.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CDH3	ad_gs_25	0.04	55.80	101.70	22.44	54.69
ad_gs_25	data_diff_CDH3	0.02	17.48	44.25	42.24	61.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_CDH3	16	16	
ad_gs_25	25	25