Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_CD33	ad_gs_25	4.99e-05	1.47e-05	1.38e-05	5.13e-06
ad_gs_25	data_diff_CD33	7.96e-01	2.87e-01	2.13e-01	5.05e-02



Evaluating how well data_diff_CD33 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CD33	ad_gs_25	0.83	2.58	5.14	3.49	5.81
ad_gs_25	data_diff_CD33	0.61	1.24	0.88	1.11	1.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_CD33	ad_gs_25	0.01	5.12	28.60	19.72	15.13
ad_gs_25	data_diff_CD33	0.01	24.78	7.86	19.24	22.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_CD33	16	16	
ad_gs_25	25	25