Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_PIAS4	ad_gs_25	2.09e-07	7.11e-10	4.17e-10	2.86e-11
ad_gs_25	data_diff_PIAS4	9.16e-01	3.31e-01	1.95e-01	5.12e-02



Evaluating how well data_diff_PIAS4 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_PIAS4	ad_gs_25	0.88	3.25	7.44	3.99	6.06
ad_gs_25	data_diff_PIAS4	0.64	1.75	1.63	1.38	1.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_PIAS4	ad_gs_25	0.04	15.03	124.71	40.40	94.90
ad_gs_25	data_diff_PIAS4	0.02	43.43	21.73	46.61	30.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_PIAS4	16	16	
ad_gs_25	25	25