Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_SLC9A5	ad_gs_25	1.62e-08	1.49e-09	1.35e-10	1.76e-11
ad_gs_25	data_diff_SLC9A5	8.52e-01	1.83e-01	7.57e-02	2.11e-02



Evaluating how well data_diff_SLC9A5 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SLC9A5	ad_gs_25	0.88	4.07	5.72	3.86	6.86
ad_gs_25	data_diff_SLC9A5	0.65	1.56	1.35	1.53	1.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_SLC9A5	ad_gs_25	0.04	30.68	105.74	36.52	69.61
ad_gs_25	data_diff_SLC9A5	0.02	22.88	23.94	21.58	34.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_SLC9A5	16	16	
ad_gs_25	25	25