Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_DAG1	ad_gs_25	3.64e-07	1.45e-08	5.34e-09	6.08e-10
ad_gs_25	data_diff_DAG1	7.69e-01	3.80e-01	1.81e-01	7.27e-02



Evaluating how well data_diff_DAG1 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_DAG1	ad_gs_25	0.88	4.32	7.13	4.10	6.23
ad_gs_25	data_diff_DAG1	0.62	1.37	1.11	1.47	1.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_DAG1	ad_gs_25	0.04	26.38	131.27	65.21	76.98
ad_gs_25	data_diff_DAG1	0.02	42.71	25.70	2.25	52.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_DAG1	16	16	
ad_gs_25	25	25