Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_EIF4E1B	ad_gs_25	1.87e-08	2.41e-09	1.20e-09	4.95e-11
ad_gs_25	data_diff_EIF4E1B	8.48e-01	2.51e-01	1.25e-01	4.32e-02



Evaluating how well data_diff_EIF4E1B genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_EIF4E1B	ad_gs_25	0.87	4.16	6.31	3.34	5.76
ad_gs_25	data_diff_EIF4E1B	0.64	2.23	1.51	1.64	1.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_EIF4E1B	ad_gs_25	0.04	51.82	112.59	36.09	95.47
ad_gs_25	data_diff_EIF4E1B	0.02	56.15	24.31	36.77	26.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_EIF4E1B	16	16	
ad_gs_25	25	25