Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_LOXHD1	ad_gs_25	1.10e-07	7.11e-10	5.86e-11	1.82e-11
ad_gs_25	data_diff_LOXHD1	8.75e-01	1.81e-01	6.72e-02	1.51e-02



Evaluating how well data_diff_LOXHD1 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_LOXHD1	ad_gs_25	0.88	4.70	6.79	4.24	6.69
ad_gs_25	data_diff_LOXHD1	0.65	1.98	1.32	1.64	2.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_LOXHD1	ad_gs_25	0.04	90.60	128.02	59.26	49.90
ad_gs_25	data_diff_LOXHD1	0.02	27.42	24.84	39.69	51.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_LOXHD1	16	16	
ad_gs_25	25	25