Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
data_diff_GTF2A2	ad_gs_25	2.15e-07	7.13e-09	4.48e-09	2.20e-10
ad_gs_25	data_diff_GTF2A2	8.41e-01	3.37e-01	1.97e-01	3.74e-02



Evaluating how well data_diff_GTF2A2 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GTF2A2	ad_gs_25	0.88	4.24	6.49	3.44	6.36
ad_gs_25	data_diff_GTF2A2	0.64	1.80	1.36	1.67	2.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
data_diff_GTF2A2	ad_gs_25	0.04	48.89	107.73	44.28	81.01
ad_gs_25	data_diff_GTF2A2	0.02	24.43	16.53	19.47	32.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
data_diff_GTF2A2	16	16	
ad_gs_25	25	25