Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
5kbalanced_regolum_z_3_173 Exclusive	tier1_31	2.08e-08	2.31e-07	3.71e-09	2.19e-09
tier1_31 Exclusive	5kbalanced_regolum_z_3_173	1.49e-01	3.03e-01	8.19e-02	1.46e-02
5kbalanced_regolum_z_3_173 Exclusive	tier1_31 Exclusive	1.10e-07	2.41e-07	9.26e-08	9.73e-08
tier1_31 Exclusive	5kbalanced_regolum_z_3_173 Exclusive	2.95e-01	5.73e-01	3.02e-02	3.27e-02
5kbalanced_regolum_z_3_173 Exclusive	Overlap	5.65e-02	1.19e-01	3.72e-02	2.85e-03
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	1.87e-03	2.67e-03	8.86e-14	2.86e-05



Evaluating how well 5kbalanced_regolum_z_3_173 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5kbalanced_regolum_z_3_173 Exclusive	tier1_31	0.85	4.75	6.61	4.60	7.86
tier1_31 Exclusive	5kbalanced_regolum_z_3_173	0.56	1.01	1.55	1.74	2.85
5kbalanced_regolum_z_3_173 Exclusive	tier1_31 Exclusive	0.84	4.05	5.64	3.90	6.28
tier1_31 Exclusive	5kbalanced_regolum_z_3_173 Exclusive	0.55	0.93	1.29	1.20	2.53
5kbalanced_regolum_z_3_173 Exclusive	Overlap	0.95	2.69	2.41	2.51	2.40
tier1_31 Exclusive	Overlap	1.00	3.08	2.35	2.84	2.88
Overlap	Exclusives	0.61	3.46	4.32	2.75	4.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5kbalanced_regolum_z_3_173 Exclusive	tier1_31	0.03	59.46	52.86	38.80	41.64
tier1_31 Exclusive	5kbalanced_regolum_z_3_173	0.02	17.15	19.63	14.91	12.97
5kbalanced_regolum_z_3_173 Exclusive	tier1_31 Exclusive	0.03	46.16	64.32	46.97	46.15
tier1_31 Exclusive	5kbalanced_regolum_z_3_173 Exclusive	0.02	10.48	16.03	11.89	14.41
5kbalanced_regolum_z_3_173 Exclusive	Overlap	0.00	6.14	8.94	10.26	3.33
tier1_31 Exclusive	Overlap	0.04	136.27	149.17	212.16	18.63
Overlap	Exclusives	0.04	24.18	41.94	17.51	30.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
5kbalanced_regolum_z_3_173 Exclusive	170	163	AC010197.2;SPECC1L-ADORA2A;AL845331.2;MARCOL;CCDC187;AC233992.2;2-Mar
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3