Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) EUR_stats_related_clean_AD_3_5 tier2_gs 3.89e-01 3.15e-01 2.05e-01 2.39e-03 tier2_gs EUR_stats_related_clean_AD_3_5 8.65e-01 8.84e-01 6.26e-03 3.87e-01 Evaluating how well EUR_stats_related_clean_AD_3_5 genes are linked to tier2_gs genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) EUR_stats_related_clean_AD_3_5 tier2_gs 0.64 0.72 1.52 1.01 3.53 tier2_gs EUR_stats_related_clean_AD_3_5 0.52 1.48 0.34 0.61 1.22 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) EUR_stats_related_clean_AD_3_5 tier2_gs 0.01 2.85 0.83 2.23 9.69 tier2_gs EUR_stats_related_clean_AD_3_5 0.02 6.86 9.48 9.76 9.99 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes EUR_stats_related_clean_AD_3_5 180 176 AC006059.2;AC093512.2;EDDM13;TM9SF1 tier2_gs 46 43 TNSF12;TNSF13;IGH