Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_regulome_5k_168 Exclusive	TIER1_GS	1.04e-08	8.99e-08	4.92e-10	2.66e-10
TIER1_GS Exclusive	sigma_regulome_5k_168	8.71e-02	1.97e-01	3.30e-02	1.97e-02
sigma_regulome_5k_168 Exclusive	TIER1_GS Exclusive	4.34e-08	1.05e-07	1.70e-08	1.33e-08
TIER1_GS Exclusive	sigma_regulome_5k_168 Exclusive	2.67e-01	4.17e-01	9.25e-02	2.53e-02
sigma_regulome_5k_168 Exclusive	Overlap	5.29e-02	1.65e-01	1.57e-02	5.00e-03
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	9.97e-04	1.48e-03	9.93e-13	5.21e-05



Evaluating how well sigma_regulome_5k_168 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_5k_168 Exclusive	TIER1_GS	0.87	4.68	6.15	4.14	8.08
TIER1_GS Exclusive	sigma_regulome_5k_168	0.57	1.34	1.62	1.96	2.93
sigma_regulome_5k_168 Exclusive	TIER1_GS Exclusive	0.86	4.18	6.47	4.36	6.36
TIER1_GS Exclusive	sigma_regulome_5k_168 Exclusive	0.56	1.02	1.34	1.69	2.64
sigma_regulome_5k_168 Exclusive	Overlap	0.96	2.49	2.23	2.56	2.75
TIER1_GS Exclusive	Overlap	1.00	2.90	2.53	2.76	2.91
Overlap	Exclusives	0.62	2.97	4.14	2.49	5.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_5k_168 Exclusive	TIER1_GS	0.04	55.51	73.89	51.91	94.39
TIER1_GS Exclusive	sigma_regulome_5k_168	0.02	13.11	23.59	19.48	14.64
sigma_regulome_5k_168 Exclusive	TIER1_GS Exclusive	0.03	60.27	71.80	57.39	52.02
TIER1_GS Exclusive	sigma_regulome_5k_168 Exclusive	0.02	11.53	15.73	14.28	8.16
sigma_regulome_5k_168 Exclusive	Overlap	0.01	9.46	10.15	12.21	11.90
TIER1_GS Exclusive	Overlap	0.04	102.32	110.24	206.35	45.39
Overlap	Exclusives	0.04	23.60	43.92	23.62	26.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_regulome_5k_168 Exclusive	165	156	AL845331.2;CCDC187;SPECC1L-ADORA2A;MARCOL;AC010197.2;C13orf46;March9;2-Mar;AC233992.2
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3