Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_splice_125_z3 Exclusive	tier1_31	5.74e-01	9.89e-01	3.94e-01	5.00e-02
tier1_31 Exclusive	sigma_splice_125_z3	8.41e-01	5.96e-02	8.98e-02	1.38e-02
sigma_splice_125_z3 Exclusive	tier1_31 Exclusive	6.61e-01	1.00e+00	6.91e-01	1.85e-01
tier1_31 Exclusive	sigma_splice_125_z3 Exclusive	5.90e-01	1.29e-01	1.01e-01	2.27e-02
sigma_splice_125_z3 Exclusive	Overlap	2.35e-01	8.36e-01	2.75e-01	1.23e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.55e-03	4.62e-04	2.76e-19	6.53e-05



Evaluating how well sigma_splice_125_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_splice_125_z3 Exclusive	tier1_31	0.61	0.65	0.16	0.57	2.12
tier1_31 Exclusive	sigma_splice_125_z3	0.57	1.37	2.37	1.70	2.87
sigma_splice_125_z3 Exclusive	tier1_31 Exclusive	0.59	0.58	0.07	0.23	1.64
tier1_31 Exclusive	sigma_splice_125_z3 Exclusive	0.56	0.90	2.09	1.28	2.31
sigma_splice_125_z3 Exclusive	Overlap	0.77	1.22	0.42	0.70	1.75
tier1_31 Exclusive	Overlap	1.00	3.04	2.20	2.87	3.06
Overlap	Exclusives	0.61	4.33	4.80	2.14	4.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_splice_125_z3 Exclusive	tier1_31	0.00	0.53	-0.17	0.19	0.04
tier1_31 Exclusive	sigma_splice_125_z3	0.01	1.26	4.11	1.18	3.82
sigma_splice_125_z3 Exclusive	tier1_31 Exclusive	0.00	0.34	-0.51	-0.05	-0.07
tier1_31 Exclusive	sigma_splice_125_z3 Exclusive	0.01	-0.20	1.22	0.09	1.14
sigma_splice_125_z3 Exclusive	Overlap	0.00	1.19	1.24	0.60	0.11
tier1_31 Exclusive	Overlap	0.03	76.42	98.90	99.42	180.39
Overlap	Exclusives	0.03	26.08	39.32	21.23	29.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_splice_125_z3 Exclusive	122	122	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3