Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigm_eqtl_z_393 Exclusive	tier1_31	6.67e-05	7.15e-05	1.66e-06	8.27e-07
tier1_31 Exclusive	sigm_eqtl_z_393	2.17e-01	3.96e-01	1.76e-01	5.77e-02
sigm_eqtl_z_393 Exclusive	tier1_31 Exclusive	1.23e-05	5.06e-05	5.39e-07	6.47e-07
tier1_31 Exclusive	sigm_eqtl_z_393 Exclusive	3.51e-01	4.77e-01	3.69e-01	5.93e-02
sigm_eqtl_z_393 Exclusive	Overlap	5.37e-01	5.17e-01	5.17e-01	3.11e-01
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	3.42e-04	2.73e-04	5.14e-19	1.13e-06



Evaluating how well sigm_eqtl_z_393 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigm_eqtl_z_393 Exclusive	tier1_31	0.79	3.26	4.80	2.84	5.14
tier1_31 Exclusive	sigm_eqtl_z_393	0.58	1.27	1.10	1.51	2.60
sigm_eqtl_z_393 Exclusive	tier1_31 Exclusive	0.79	3.11	4.75	2.80	5.44
tier1_31 Exclusive	sigm_eqtl_z_393 Exclusive	0.57	0.74	0.90	1.05	2.06
sigm_eqtl_z_393 Exclusive	Overlap	0.81	0.76	1.00	0.87	1.44
tier1_31 Exclusive	Overlap	1.00	2.64	1.87	2.13	2.27
Overlap	Exclusives	0.66	5.01	5.10	2.96	6.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigm_eqtl_z_393 Exclusive	tier1_31	0.01	13.35	22.79	9.52	8.06
tier1_31 Exclusive	sigm_eqtl_z_393	0.01	7.31	6.16	7.29	4.41
sigm_eqtl_z_393 Exclusive	tier1_31 Exclusive	0.01	9.13	14.16	10.29	1.85
tier1_31 Exclusive	sigm_eqtl_z_393 Exclusive	0.01	4.39	5.69	3.71	5.65
sigm_eqtl_z_393 Exclusive	Overlap	0.01	7.25	149.51	16.47	12.65
tier1_31 Exclusive	Overlap	0.02	35.40	47.91	17.08	7.21
Overlap	Exclusives	0.02	21.99	20.41	10.07	12.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigm_eqtl_z_393 Exclusive	91	90	CLEC20A
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2