Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_spliceai_100_5k Exclusive	ad_tier1_31	1.48e-01	5.80e-01	3.30e-01	1.98e-01
ad_tier1_31 Exclusive	sigma_spliceai_100_5k	8.26e-01	9.99e-02	3.96e-01	1.18e-01
sigma_spliceai_100_5k Exclusive	ad_tier1_31 Exclusive	2.85e-01	6.13e-01	6.39e-01	3.99e-01
ad_tier1_31 Exclusive	sigma_spliceai_100_5k Exclusive	8.13e-01	2.59e-01	2.83e-01	2.98e-01
sigma_spliceai_100_5k Exclusive	Overlap	2.35e-01	7.04e-01	4.24e-01	1.98e-01
ad_tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	9.75e-04	2.48e-04	8.03e-17	1.67e-04



Evaluating how well sigma_spliceai_100_5k genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_spliceai_100_5k Exclusive	ad_tier1_31	0.60	0.72	0.04	0.22	1.91
ad_tier1_31 Exclusive	sigma_spliceai_100_5k	0.55	1.11	2.30	1.39	2.06
sigma_spliceai_100_5k Exclusive	ad_tier1_31 Exclusive	0.58	0.47	-0.02	-0.04	1.53
ad_tier1_31 Exclusive	sigma_spliceai_100_5k Exclusive	0.54	0.99	1.47	0.97	1.18
sigma_spliceai_100_5k Exclusive	Overlap	0.77	1.28	0.47	0.66	1.79
ad_tier1_31 Exclusive	Overlap	1.00	2.73	2.39	2.66	2.68
Overlap	Exclusives	0.61	4.16	4.64	2.68	3.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_spliceai_100_5k Exclusive	ad_tier1_31	0.00	0.47	-0.26	-0.02	0.77
ad_tier1_31 Exclusive	sigma_spliceai_100_5k	0.01	2.01	4.58	0.82	2.75
sigma_spliceai_100_5k Exclusive	ad_tier1_31 Exclusive	0.00	0.36	-0.31	-0.25	-0.07
ad_tier1_31 Exclusive	sigma_spliceai_100_5k Exclusive	0.01	-0.12	0.58	-0.18	0.17
sigma_spliceai_100_5k Exclusive	Overlap	0.00	0.69	0.66	0.20	-0.07
ad_tier1_31 Exclusive	Overlap	0.03	49.21	106.14	125.49	35.75
Overlap	Exclusives	0.03	33.10	42.11	21.90	18.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_spliceai_100_5k Exclusive	97	97	
ad_tier1_31 Exclusive	28	27	MS4A
Overlap	3	3