Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_qtl_5k_100 Exclusive	ad_tier1_31	2.05e-06	1.81e-06	8.89e-09	9.84e-09
ad_tier1_31 Exclusive	sigma_qtl_5k_100	1.88e-01	1.86e-01	1.18e-01	9.07e-03
sigma_qtl_5k_100 Exclusive	ad_tier1_31 Exclusive	4.49e-07	4.60e-07	4.54e-09	1.54e-08
ad_tier1_31 Exclusive	sigma_qtl_5k_100 Exclusive	3.84e-01	2.17e-01	2.18e-01	1.90e-02
sigma_qtl_5k_100 Exclusive	Overlap	5.37e-01	5.17e-01	4.12e-01	1.63e-01
ad_tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	3.85e-04	2.32e-04	4.74e-24	3.43e-07



Evaluating how well sigma_qtl_5k_100 genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_qtl_5k_100 Exclusive	ad_tier1_31	0.82	3.79	6.05	3.72	6.64
ad_tier1_31 Exclusive	sigma_qtl_5k_100	0.59	1.83	1.75	1.98	3.10
sigma_qtl_5k_100 Exclusive	ad_tier1_31 Exclusive	0.82	3.49	6.74	3.45	5.58
ad_tier1_31 Exclusive	sigma_qtl_5k_100 Exclusive	0.58	1.70	1.65	1.43	2.81
sigma_qtl_5k_100 Exclusive	Overlap	0.87	1.19	1.47	1.58	1.88
ad_tier1_31 Exclusive	Overlap	1.00	2.51	1.82	2.18	2.23
Overlap	Exclusives	0.66	4.60	5.48	3.06	6.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_qtl_5k_100 Exclusive	ad_tier1_31	0.02	18.85	40.96	8.47	33.96
ad_tier1_31 Exclusive	sigma_qtl_5k_100	0.01	10.78	10.94	11.45	12.96
sigma_qtl_5k_100 Exclusive	ad_tier1_31 Exclusive	0.02	19.71	40.60	22.07	25.93
ad_tier1_31 Exclusive	sigma_qtl_5k_100 Exclusive	0.01	9.50	8.66	6.39	4.34
sigma_qtl_5k_100 Exclusive	Overlap	0.01	6.02	193.82	25.76	27.65
ad_tier1_31 Exclusive	Overlap	0.02	28.89	51.26	71.75	44.40
Overlap	Exclusives	0.02	23.74	20.68	2.93	22.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_qtl_5k_100 Exclusive	98	97	CLEC20A
ad_tier1_31 Exclusive	29	28	MS4A
Overlap	2	2