Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_regulome_5k_100 Exclusive	ad_tier1_31	8.99e-08	4.11e-08	2.37e-09	1.23e-10
ad_tier1_31 Exclusive	sigma_regulome_5k_100	1.22e-01	2.76e-01	2.40e-02	5.73e-02
sigma_regulome_5k_100 Exclusive	ad_tier1_31 Exclusive	3.70e-07	5.74e-08	2.21e-08	4.74e-09
ad_tier1_31 Exclusive	sigma_regulome_5k_100 Exclusive	3.93e-01	5.81e-01	1.14e-01	1.32e-01
sigma_regulome_5k_100 Exclusive	Overlap	1.45e-01	2.61e-01	1.50e-01	1.57e-02
ad_tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.43e-04	4.78e-05	2.36e-14	1.18e-06



Evaluating how well sigma_regulome_5k_100 genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_5k_100 Exclusive	ad_tier1_31	0.85	4.37	6.45	4.19	6.31
ad_tier1_31 Exclusive	sigma_regulome_5k_100	0.58	1.87	1.68	2.13	2.68
sigma_regulome_5k_100 Exclusive	ad_tier1_31 Exclusive	0.84	4.29	5.38	3.64	6.57
ad_tier1_31 Exclusive	sigma_regulome_5k_100 Exclusive	0.57	1.28	1.52	1.93	2.24
sigma_regulome_5k_100 Exclusive	Overlap	0.91	1.99	1.84	1.98	2.43
ad_tier1_31 Exclusive	Overlap	1.00	3.08	2.80	2.59	2.75
Overlap	Exclusives	0.67	4.32	6.17	3.42	5.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_5k_100 Exclusive	ad_tier1_31	0.02	19.04	32.15	22.71	11.27
ad_tier1_31 Exclusive	sigma_regulome_5k_100	0.02	19.26	18.21	18.91	20.41
sigma_regulome_5k_100 Exclusive	ad_tier1_31 Exclusive	0.01	22.21	26.71	7.65	19.13
ad_tier1_31 Exclusive	sigma_regulome_5k_100 Exclusive	0.01	9.00	10.71	13.51	5.60
sigma_regulome_5k_100 Exclusive	Overlap	0.00	6.68	4.42	7.05	4.77
ad_tier1_31 Exclusive	Overlap	0.04	142.91	127.58	229.72	183.11
Overlap	Exclusives	0.04	18.73	51.92	31.29	42.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_regulome_5k_100 Exclusive	97	92	SPECC1L-ADORA2A;March9;CCDC187;AC010197.2;AL845331.2
ad_tier1_31 Exclusive	28	27	MS4A
Overlap	3	3