Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_proxy Exclusive	Ismael	8.29e-03	5.65e-02	2.74e-03	4.31e-05
Ismael Exclusive	AD_proxy	9.68e-02	1.17e-01	8.39e-05	5.78e-03
AD_proxy Exclusive	Ismael Exclusive	2.67e-02	1.05e-01	1.87e-03	2.66e-04
Ismael Exclusive	AD_proxy Exclusive	6.10e-02	2.42e-01	4.10e-05	1.08e-02
AD_proxy Exclusive	Overlap	1.78e-01	1.98e-02	1.58e-01	1.39e-01
Ismael Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.00e-04	1.87e-03	3.52e-16	2.20e-06



Evaluating how well AD_proxy genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_proxy Exclusive	Ismael	0.84	3.17	3.33	1.93	4.43
Ismael Exclusive	AD_proxy	0.60	2.04	2.48	2.30	3.17
AD_proxy Exclusive	Ismael Exclusive	0.84	2.80	2.86	2.47	5.00
Ismael Exclusive	AD_proxy Exclusive	0.59	1.47	2.07	1.94	2.70
AD_proxy Exclusive	Overlap	0.94	1.26	1.78	1.12	1.36
Ismael Exclusive	Overlap	1.00	2.15	1.75	1.91	1.81
Overlap	Exclusives	0.64	2.79	4.40	2.66	5.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_proxy Exclusive	Ismael	0.01	13.47	10.35	7.06	7.44
Ismael Exclusive	AD_proxy	0.01	5.91	7.55	7.78	3.83
AD_proxy Exclusive	Ismael Exclusive	0.01	12.24	9.59	12.00	12.66
Ismael Exclusive	AD_proxy Exclusive	0.01	2.63	5.64	4.64	5.84
AD_proxy Exclusive	Overlap	0.00	0.51	5.35	0.41	0.47
Ismael Exclusive	Overlap	0.02	52.02	143.89	76.31	115.78
Overlap	Exclusives	0.01	8.97	11.71	7.44	6.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_proxy Exclusive	94	91	SERPINA3;KDM5D;TMEM265
Ismael Exclusive	13	13	
Overlap	1	1